6KUB
Crystal structure of Plasmodium falciparum histo-aspartic protease (HAP) zymogen (Form 1)
Summary for 6KUB
Entry DOI | 10.2210/pdb6kub/pdb |
Descriptor | HAP protein, GLYCEROL, DI(HYDROXYETHYL)ETHER, ... (4 entities in total) |
Functional Keywords | histo-aspartic protease, hap, plasmepsin, proplasmepsin, zymogen, aspartic protease, hydrolase |
Biological source | Plasmodium falciparum |
Total number of polymer chains | 1 |
Total formula weight | 43919.70 |
Authors | Rathore, I.,Mishra, V.,Bhaumik, P. (deposition date: 2019-08-31, release date: 2020-05-27, Last modification date: 2023-11-22) |
Primary citation | Rathore, I.,Mishra, V.,Patel, C.,Xiao, H.,Gustchina, A.,Wlodawer, A.,Yada, R.Y.,Bhaumik, P. Activation mechanism of plasmepsins, pepsin-like aspartic proteases from Plasmodium, follows a unique trans-activation pathway. Febs J., 288:678-698, 2021 Cited by PubMed: 32385863DOI: 10.1111/febs.15363 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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