6KPP
BNC105 in complex with tubulin
Summary for 6KPP
Entry DOI | 10.2210/pdb6kpp/pdb |
Descriptor | Tubulin alpha-1B chain, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLYCEROL, ... (12 entities in total) |
Functional Keywords | bnc105, tubulin, protein-drug complex, antitumor protein |
Biological source | Mus musculus (Mouse) More |
Total number of polymer chains | 6 |
Total formula weight | 264734.52 |
Authors | |
Primary citation | Wang, T.,Wu, C.,Wang, C.,Zhang, G.,Arnst, K.E.,Yao, Y.,Zhang, Z.,Wang, Y.,Pu, D.,Li, W. Unraveling the molecular mechanism of BNC105, a phase II clinical trial vascular disrupting agent, provides insights into drug design. Biochem.Biophys.Res.Commun., 2020 Cited by PubMed: 32085900DOI: 10.1016/j.bbrc.2019.12.083 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.74524106157 Å) |
Structure validation
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