6KPF

Cryo-EM structure of a class A GPCR with G protein complex

6KPF の概要

• エントリーDOI: 10.2210/pdb6kpf/pdb
• EMDBエントリー: 0744
• 分子名称: Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total)
• 機能のキーワード: gpcr, gi protein, membrane protein
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 5
• 化学式量合計: 153600.28

構造登録者

Li, X.T.,Hua, T.,Wu, L.J.,Makriyannis, A.,Shen, L.,Wang, Y.X.,Liu, Z.J. (登録日: 2019-08-15, 公開日: 2020-02-12, 最終更新日: 2022-04-27)

• 主引用文献: Hua, T.,Li, X.,Wu, L.,Iliopoulos-Tsoutsouvas, C.,Wang, Y.,Wu, M.,Shen, L.,Johnston, C.A.,Nikas, S.P.,Song, F.,Song, X.,Yuan, S.,Sun, Q.,Wu, Y.,Jiang, S.,Grim, T.W.,Benchama, O.,Stahl, E.L.,Zvonok, N.,Zhao, S.,Bohn, L.M.,Makriyannis, A.,Liu, Z.J.; Activation and Signaling Mechanism Revealed by Cannabinoid Receptor-GiComplex Structures.; Cell, 180:655-, 2020; PubMed: 32004463; DOI: 10.1016/j.cell.2020.01.008

実験手法

ELECTRON MICROSCOPY (2.9 Å)