6KP2
Quadruple mutant plasmodium falciparum dihydrofolate reductase complexed with B10042
6KP2 の概要
エントリーDOI | 10.2210/pdb6kp2/pdb |
分子名称 | Bifunctional dihydrofolate reductase-thymidylate synthase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 5-(3-chlorophenyl)-6-(3-phenoxypropyl)pyrimidine-2,4-diamine, ... (6 entities in total) |
機能のキーワード | dihydrofolate reductase, plasmodium falciparum, antimalarial, antifolate, antibiotic, oxidoreductase, transferase |
由来する生物種 | Plasmodium falciparum (malaria parasite P. falciparum) |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 146390.90 |
構造登録者 | |
主引用文献 | Saepua, S.,Sadorn, K.,Vanichtanankul, J.,Anukunwithaya, T.,Rattanajak, R.,Vitsupakorn, D.,Kamchonwongpaisan, S.,Yuthavong, Y.,Thongpanchang, C. 6-Hydrophobic aromatic substituent pyrimethamine analogues as potential antimalarials for pyrimethamine-resistant Plasmodium falciparum. Bioorg.Med.Chem., 27:115158-115158, 2019 Cited by PubMed: 31685330DOI: 10.1016/j.bmc.2019.115158 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.973 Å) |
構造検証レポート
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