6KO0
The crystal structue of PDE10A complexed with 1i
Summary for 6KO0
Entry DOI | 10.2210/pdb6ko0/pdb |
Descriptor | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, 3-[2-(5-methyl-1-phenyl-benzimidazol-2-yl)ethyl]chromen-4-one, ZINC ION, ... (5 entities in total) |
Functional Keywords | pde10a inhibitor, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 75524.33 |
Authors | Huang, Y.-Y.,Yu, Y.F.,Zhang, C.,Guo, L.,Wu, D.,Luo, H.-B. (deposition date: 2019-08-07, release date: 2020-04-01, Last modification date: 2023-11-22) |
Primary citation | Yu, Y.F.,Zhang, C.,Huang, Y.Y.,Zhang, S.,Zhou, Q.,Li, X.,Lai, Z.,Li, Z.,Gao, Y.,Wu, Y.,Guo, L.,Wu, D.,Luo, H.B. Discovery and Optimization of Chromone Derivatives as Novel Selective Phosphodiesterase 10 Inhibitors. Acs Chem Neurosci, 11:1058-1071, 2020 Cited by PubMed: 32105440DOI: 10.1021/acschemneuro.0c00024 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.60002905998 Å) |
Structure validation
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