6KO0

The crystal structue of PDE10A complexed with 1i

Summary for 6KO0

• Entry DOI: 10.2210/pdb6ko0/pdb
• Descriptor: cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, 3-[2-(5-methyl-1-phenyl-benzimidazol-2-yl)ethyl]chromen-4-one, ZINC ION, ... (5 entities in total)
• Functional Keywords: pde10a inhibitor, hydrolase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 75524.33

Authors

Huang, Y.-Y.,Yu, Y.F.,Zhang, C.,Guo, L.,Wu, D.,Luo, H.-B. (deposition date: 2019-08-07, release date: 2020-04-01, Last modification date: 2023-11-22)

• Primary citation: Yu, Y.F.,Zhang, C.,Huang, Y.Y.,Zhang, S.,Zhou, Q.,Li, X.,Lai, Z.,Li, Z.,Gao, Y.,Wu, Y.,Guo, L.,Wu, D.,Luo, H.B.; Discovery and Optimization of Chromone Derivatives as Novel Selective Phosphodiesterase 10 Inhibitors.; Acs Chem Neurosci, 11:1058-1071, 2020; PubMed: 32105440; DOI: 10.1021/acschemneuro.0c00024

Experimental method

X-RAY DIFFRACTION (2.60002905998 Å)