6KL5

Structure of The N-terminal domain of Middle East respiratory syndrome coronavirus Nucleocapsid Protein complexed with Benzyl 2-(Hydroxymethyl)-1-Indolinecarboxylate

6KL5 の概要

• エントリーDOI: 10.2210/pdb6kl5/pdb
• 分子名称: Nucleoprotein, (phenylmethyl) (2S)-2-(hydroxymethyl)-2,3-dihydroindole-1-carboxylate (2 entities in total)
• 機能のキーワード: middle east respiratory syndrome coronavirus; nucleocapsid protein; n-terminal domain; benzyl 2-(hydroxymethyl)-1-indoline carboxylate, virus, viral protein
• 由来する生物種: Middle East respiratory syndrome-related coronavirus
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 63705.59

構造登録者

Hou, M.H.,Lin, S.M.,Hsu, J.N.,Wang, Y.S. (登録日: 2019-07-29, 公開日: 2020-03-25, 最終更新日: 2023-11-22)

• 主引用文献: Lin, S.M.,Lin, S.C.,Hsu, J.N.,Chang, C.K.,Chien, C.M.,Wang, Y.S.,Wu, H.Y.,Jeng, U.S.,Kehn-Hall, K.,Hou, M.H.; Structure-Based Stabilization of Non-native Protein-Protein Interactions of Coronavirus Nucleocapsid Proteins in Antiviral Drug Design.; J.Med.Chem., 63:3131-3141, 2020; PubMed: 32105468; DOI: 10.1021/acs.jmedchem.9b01913

実験手法

X-RAY DIFFRACTION (3.09 Å)