6KK6

Crystal structure of Zika NS2B-NS3 protease with compound 16

Summary for 6KK6

Entry DOI	10.2210/pdb6kk6/pdb
Descriptor	Serine protease subunit NS2B, NS3 protease, SULFATE ION, ... (6 entities in total)
Functional Keywords	viral protease, protease inhibitor complex, viral protein
Biological source	Zika virus (ZIKV) More
Total number of polymer chains	2
Total formula weight	25735.94
Authors	Quek, J.P. (deposition date: 2019-07-23, release date: 2020-06-17, Last modification date: 2023-11-22)
Primary citation	Braun, N.J.,Quek, J.P.,Huber, S.,Kouretova, J.,Rogge, D.,Lang-Henkel, H.,Cheong, E.Z.K.,Chew, B.L.A.,Heine, A.,Luo, D.,Steinmetzer, T. Structure-Based Macrocyclization of Substrate Analogue NS2B-NS3 Protease Inhibitors of Zika, West Nile and Dengue viruses. Chemmedchem, 15:1439-1452, 2020 Cited by PubMed: 32501637 DOI: 10.1002/cmdc.202000237 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.74 Å)

Structure validation