6KJD
lovastatin esterase PcEST inactive mutant S57A in complex with lovastatin
Summary for 6KJD
Entry DOI | 10.2210/pdb6kjd/pdb |
Descriptor | Pc15g00720 protein, (3R,5R)-7-((1R,2R,6S,8R,8AS)-2,6-DIMETHYL-8-{[(2R)-2-METHYLBUTANOYL]OXY}-1,2,6,7,8,8A-HEXAHYDRONAPHTHALEN-1-YL)-3,5-DIHYDROXYHEPTANOIC ACID, TRIS-HYDROXYMETHYL-METHYL-AMMONIUM, ... (4 entities in total) |
Functional Keywords | family viii esterase, lovastatin hydrolysis, monacolin j, simvastatin, hydrolase |
Biological source | Penicillium rubens Wisconsin 54-1255 |
Total number of polymer chains | 2 |
Total formula weight | 88368.10 |
Authors | Liang, Y.J.,Lu, X.F. (deposition date: 2019-07-22, release date: 2019-12-25, Last modification date: 2023-11-22) |
Primary citation | Liang, Y.J.,Lu, X.F. Structural insights into the catalytic mechanism of lovastatin hydrolase J.Biol.Chem., 2019 Cited by DOI: 10.1074/jbc.RA119.011936PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.299 Å) |
Structure validation
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