6KJ8
E. coli ATCase holoenzyme mutant - G166P (catalytic chain)
Summary for 6KJ8
Entry DOI | 10.2210/pdb6kj8/pdb |
Descriptor | Aspartate carbamoyltransferase catalytic subunit, Aspartate carbamoyltransferase regulatory chain, ZINC ION, ... (4 entities in total) |
Functional Keywords | aspartate transcarbamoylase holoenzyme, de novo pyrimidine biosynthesis, transferase |
Biological source | Escherichia coli K-12 More |
Total number of polymer chains | 6 |
Total formula weight | 154758.62 |
Authors | |
Primary citation | Lei, Z.,Wang, B.,Lu, Z.,Wang, N.,Tan, H.,Zheng, J.,Jia, Z. New regulatory mechanism-based inhibitors of aspartate transcarbamoylase for potential anticancer drug development. Febs J., 287:3579-3599, 2020 Cited by PubMed: 31967710DOI: 10.1111/febs.15220 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.011 Å) |
Structure validation
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