6KGM

LSD1-CoREST-S2116 five-membered ring adduct model

Summary for 6KGM

• Entry DOI: 10.2210/pdb6kgm/pdb
• Descriptor: Lysine-specific histone demethylase 1A, REST corepressor 1, GLYCEROL, ... (6 entities in total)
• Functional Keywords: demethylase, amine oxidase, chromatin, histone, fad, mechanism-based inhibitor, oxidoreductase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 91706.27

Authors

Niwa, H.,Sato, S.,Umehara, T. (deposition date: 2019-07-12, release date: 2020-03-25, Last modification date: 2024-03-27)

• Primary citation: Niwa, H.,Sato, S.,Handa, N.,Sengoku, T.,Umehara, T.,Yokoyama, S.; Development and Structural Evaluation of N-Alkylated trans-2-Phenylcyclopropylamine-Based LSD1 Inhibitors.; Chemmedchem, 15:787-793, 2020; PubMed: 32166890; DOI: 10.1002/cmdc.202000014

Experimental method

X-RAY DIFFRACTION (2.62 Å)