6KG2
Human MTHFD2 in complex with Compound 18
Summary for 6KG2
Entry DOI | 10.2210/pdb6kg2/pdb |
Descriptor | Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial, N-[2-chloranyl-4-[[7-methyl-8-(4-methylpiperazin-1-yl)-5-oxidanylidene-2,4-dihydro-1H-chromeno[3,4-c]pyridin-3-yl]carbonyl]phenyl]methanesulfonamide, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... (5 entities in total) |
Functional Keywords | inhibitor, folate, cofactor, dehydrogenase, oxidoreductase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 73037.83 |
Authors | Suzuki, M.,Matsui, Y.,Ota, M.,Kawai, J. (deposition date: 2019-07-10, release date: 2019-11-13, Last modification date: 2024-03-27) |
Primary citation | Kawai, J.,Toki, T.,Ota, M.,Inoue, H.,Takata, Y.,Asahi, T.,Suzuki, M.,Shimada, T.,Ono, K.,Suzuki, K.,Takaishi, S.,Ohki, H.,Matsui, S.,Tsutsumi, S.,Hirota, Y.,Nakayama, K. Discovery of a Potent, Selective, and Orally Available MTHFD2 Inhibitor (DS18561882) with in Vivo Antitumor Activity. J.Med.Chem., 62:10204-10220, 2019 Cited by PubMed: 31638799DOI: 10.1021/acs.jmedchem.9b01113 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.25 Å) |
Structure validation
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