6KFT

MVM NS2 mutant Nm42 in complex with CRM1-Ran-RanBP1

6KFT の概要

• エントリーDOI: 10.2210/pdb6kft/pdb
• 関連するPDBエントリー: 6A38 6A3A 6A3B 6A3C 6A3E
• 分子名称: GTP-binding nuclear protein Ran, Ran-specific GTPase-activating protein 1, Exportin-1, ... (10 entities in total)
• 機能のキーワード: transport protein, nuclear export, complex, mutant, inhibitor
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 160864.32

構造登録者

Sun, Q.,Li, Y. (登録日: 2019-07-08, 公開日: 2020-07-15, 最終更新日: 2023-11-22)

主引用文献

Sui, M.,Xiong, M.,Li, Y.,Zhou, Q.,Shen, X.,Jia, D.,Gou, M.,Sun, Q.
Cancer Therapy with Nanoparticle-Medicated Intracellular Expression of Peptide CRM1-Inhibitor.
Int J Nanomedicine, 16:2833-2847, 2021

PubMed Abstract: Peptides can be rationally designed as non-covalent inhibitors for molecularly targeted therapy. However, it remains challenging to efficiently deliver the peptides into the targeted cells, which often severely affects their therapeutic efficiency.

PubMed: 33883894
DOI: 10.2147/IJN.S266398

実験手法

X-RAY DIFFRACTION (2.51 Å)