6KEE

Crystal structure of BRD4 Bromodomain1 with an inhibitor

6KEE の概要

• エントリーDOI: 10.2210/pdb6kee/pdb
• 分子名称: Bromodomain-containing protein 4, 6-[2-[2,4-bis(fluoranyl)phenoxy]-5-(methylsulfonylmethyl)pyridin-3-yl]-8-methyl-2H-pyrrolo[1,2-a]pyrazin-1-one (3 entities in total)
• 機能のキーワード: antitumor, bet proteins, bromodomain inhibitor, epigenetic readers, antitumor protein, transcription
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 15544.82

構造登録者

Xiao, S.,Li, Z.,Chen, S.,Zhou, B.,Luo, C. (登録日: 2019-07-04, 公開日: 2020-07-08, 最終更新日: 2023-11-22)

• 主引用文献: Xiao, S.,Li, Z.,Chen, S.,Zhou, B.,Luo, C.; Crystal structure of BRD4 Bromodomain1 with an inhibitor; To be published,

実験手法

X-RAY DIFFRACTION (2.12154661767 Å)