6KE2

ABloop reengineered Ferritin Nanocage

6KE2 の概要

• エントリーDOI: 10.2210/pdb6ke2/pdb
• 分子名称: Ferritin heavy chain, MAGNESIUM ION, FE (III) ION, ... (6 entities in total)
• 機能のキーワード: rhuhf, abloop reengineered, metal binding protein
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 21368.63

構造登録者

Wang, W.M.,Wang, H.F. (登録日: 2019-07-03, 公開日: 2019-10-23, 最終更新日: 2023-11-22)

主引用文献

Wang, W.,Wang, L.,Li, G.,Zhao, G.,Zhao, X.,Wang, H.
AB loop engineered ferritin nanocages for drug loading under benign experimental conditions.
Chem.Commun.(Camb.), 55:12344-12347, 2019

PubMed Abstract: Human ferritin has been explored as a potential drug nanocarrier, but extreme conditions (pH ≤ 2.0) are required for the encapsulation of drugs. Here, by engineering the AB loop of ferritin, we obtained a new ferritin variant with no new pores, which can disassemble at pH 3.0 or 4.0 and reassemble at pH 7.0. Consequently, under mild conditions, drugs can be encapsulated within this new ferritin nanocage.

PubMed: 31556881
DOI: 10.1039/c9cc05247j

実験手法

X-RAY DIFFRACTION (1.798 Å)