6KCL
Crystal structure of Plasmodium falciparum HPPK-DHPS A437G/K540E with pterin and p-hydroxybenzoate
Summary for 6KCL
Entry DOI | 10.2210/pdb6kcl/pdb |
Descriptor | 7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase-dihydropteroate synthase, PTERINE, P-HYDROXYBENZOIC ACID, ... (9 entities in total) |
Functional Keywords | tim barrel, kinase, transferase |
Biological source | Plasmodium falciparum |
Total number of polymer chains | 2 |
Total formula weight | 173934.72 |
Authors | Chitnumsub, P.,Jaruwat, A.,Yuthavong, Y. (deposition date: 2019-06-28, release date: 2020-02-12, Last modification date: 2023-11-22) |
Primary citation | Chitnumsub, P.,Jaruwat, A.,Talawanich, Y.,Noytanom, K.,Liwnaree, B.,Poen, S.,Yuthavong, Y. The structure of Plasmodium falciparum hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase reveals the basis of sulfa resistance. Febs J., 287:3273-3297, 2020 Cited by PubMed: 31883412DOI: 10.1111/febs.15196 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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