6K6U

Crystal structure of the human YTHDC2 YTH domain

Summary for 6K6U

• Entry DOI: 10.2210/pdb6k6u/pdb
• Descriptor: 3'-5' RNA helicase YTHDC2 (2 entities in total)
• Functional Keywords: ythdc2, yth, m6a, structural genomics, structural genomics consortium, sgc, hydrolase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 33105.51

Authors

Ma, C.,Liao, S.,Xu, C. (deposition date: 2019-06-04, release date: 2019-12-25, Last modification date: 2023-11-22)

Primary citation

Ma, C.,Liao, S.,Zhu, Z.
Crystal structure of human YTHDC2 YTH domain.
Biochem.Biophys.Res.Commun., 518:678-684, 2019

PubMed Abstract: N-methyladenosine (mA) "readers" play an important role in mRNA functions and metabolism. YTHDC2, as one of the mA readers, controls fertileness through decreasing associated mRNA abundance and enhancing the translation efficiency of related mRNA via binding the targeted mA RNA. However, how YTH domain of YTHDC2 recognize mA RNA is still unknown. In this study, we determined the crystal structure of human YTHDC2 YTH domain, which adopts similar architecture to other solved YTH domain structures. YTHDC2 contains a conserved mA binding pocket, and similar RNA binding surface shared by YTHDC1.

PubMed: 31472957
DOI: 10.1016/j.bbrc.2019.08.107

Experimental method

X-RAY DIFFRACTION (2.27 Å)