6K5O

Development of Novel Lithocholic Acid Derivatives as Vitamin D Receptor Agonists

Summary for 6K5O

Entry DOI	10.2210/pdb6k5o/pdb
Descriptor	Vitamin D3 receptor, Mediator of RNA polymerase II transcription subunit 1, (4~{R})-4-[(3~{R},5~{R},8~{R},9~{S},10~{S},13~{R},14~{S},17~{R})-10,13-dimethyl-3-methylsulfonyloxy-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1~{H}-cyclopenta[a]phenanthren-17-yl]pentanoic acid, ... (4 entities in total)
Functional Keywords	vitamin d receptor, transcription
Biological source	Rattus norvegicus (Rat) More
Total number of polymer chains	2
Total formula weight	32620.60
Authors	Masuno, H.,Kagechika, H.,Ito, N. (deposition date: 2019-05-29, release date: 2019-07-24, Last modification date: 2023-11-22)
Primary citation	Masuno, H.,Kazui, Y.,Tanatani, A.,Fujii, S.,Kawachi, E.,Ikura, T.,Ito, N.,Yamamoto, K.,Kagechika, H. Development of novel lithocholic acid derivatives as vitamin D receptor agonists. Bioorg.Med.Chem., 27:3674-3681, 2019 Cited by PubMed: 31300316 DOI: 10.1016/j.bmc.2019.07.003 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation