6JXT

Crystal structure of EGFR 696-1022 WT in complex with AZD9291 prepared by cocrystallization

Summary for 6JXT

Entry DOI	10.2210/pdb6jxt/pdb
Related	6JWL 6JX0 6JX4
Descriptor	Epidermal growth factor receptor, N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)prop-2-enamide, CHLORIDE ION, ... (4 entities in total)
Functional Keywords	complex, inhibitor, egfr, oncoprotein, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	37981.40
Authors	Yun, C.H.,Zhu, S.J.,Yan, X.E. (deposition date: 2019-04-25, release date: 2020-04-29, Last modification date: 2020-11-04)
Primary citation	Yan, X.E.,Ayaz, P.,Zhu, S.J.,Zhao, P.,Liang, L.,Zhang, C.H.,Wu, Y.C.,Li, J.L.,Choi, H.G.,Huang, X.,Shan, Y.,Shaw, D.E.,Yun, C.H. Structural Basis of AZD9291 Selectivity for EGFR T790M. J.Med.Chem., 63:8502-8511, 2020 Cited by PubMed: 32672461 DOI: 10.1021/acs.jmedchem.0c00891 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.307 Å)

Structure validation