6JX4
Crystal structure of EGFR 696-1022 T790M in complex with AZD9291 prepared by soaking
Summary for 6JX4
Entry DOI | 10.2210/pdb6jx4/pdb |
Related | 6JWL 6JX0 |
Descriptor | Epidermal growth factor receptor, N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)prop-2-enamide (3 entities in total) |
Functional Keywords | complex, inhibitor, egfr., oncoprotein, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 38150.21 |
Authors | |
Primary citation | Yan, X.E.,Ayaz, P.,Zhu, S.J.,Zhao, P.,Liang, L.,Zhang, C.H.,Wu, Y.C.,Li, J.L.,Choi, H.G.,Huang, X.,Shan, Y.,Shaw, D.E.,Yun, C.H. Structural Basis of AZD9291 Selectivity for EGFR T790M. J.Med.Chem., 63:8502-8511, 2020 Cited by PubMed: 32672461DOI: 10.1021/acs.jmedchem.0c00891 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.531 Å) |
Structure validation
Download full validation report