6JWE

structure of RET G-quadruplex in complex with colchicine

6JWE の概要

• エントリーDOI: 10.2210/pdb6jwe/pdb
• 関連するPDBエントリー: 2L88
• 分子名称: DNA (5'-D(*GP*GP*GP*GP*CP*GP*GP*GP*GP*CP*GP*GP*GP*GP*CP*GP*GP*GP*GP*T)-3'), N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[d]heptalen-7-yl]ethanamide (2 entities in total)
• 機能のキーワード: ret, g-quadruplex, colchicine, dna
• 由来する生物種: Homo sapiens
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 6793.51

構造登録者

Wang, F.,Wang, C.,Liu, Y.,Lan, W.X.,Li, Y.M.,Wang, R.X.,Cao, C. (登録日: 2019-04-20, 公開日: 2020-02-26, 最終更新日: 2024-05-15)

主引用文献

Wang, F.,Wang, C.,Liu, Y.,Lan, W.,Han, H.,Wang, R.,Huang, S.,Cao, C.
Colchicine selective interaction with oncogene RET G-quadruplex revealed by NMR.
Chem.Commun.(Camb.), 56:2099-2102, 2020

PubMed Abstract: G-quadruplexes (G4s) are frequently formed in the promoter regions of oncogenes, considered as promising drug targets for anticancer therapy. Due to high structure similarity of G4s, discovering ligands selectively interacting with only one G4 is extremely difficult. Here, mainly by NMR, we report that colchicine selectively binds to oncogene RET G4-DNA.

PubMed: 32025680
DOI: 10.1039/d0cc00221f

実験手法

SOLUTION NMR