6JQR
Crystal structure of FLT3 in complex with gilteritinib
Summary for 6JQR
| Entry DOI | 10.2210/pdb6jqr/pdb |
| Descriptor | Receptor-type tyrosine-protein kinase FLT3,Receptor-type tyrosine-protein kinase FLT3, 6-ethyl-3-[[3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]amino]-5-(oxan-4-ylamino)pyrazine-2-carboxamide, SULFATE ION, ... (6 entities in total) |
| Functional Keywords | protein kinase, oncoprotein, transferase |
| Biological source | Homo sapiens (Human) More |
| Total number of polymer chains | 1 |
| Total formula weight | 39337.74 |
| Authors | Amano, Y. (deposition date: 2019-04-01, release date: 2019-11-20, Last modification date: 2024-03-27) |
| Primary citation | Kawase, T.,Nakazawa, T.,Eguchi, T.,Tsuzuki, H.,Ueno, Y.,Amano, Y.,Suzuki, T.,Mori, M.,Yoshida, T. Effect of Fms-like tyrosine kinase 3 (FLT3) ligand (FL) on antitumor activity of gilteritinib, a FLT3 inhibitor, in mice xenografted with FL-overexpressing cells. Oncotarget, 10:6111-6123, 2019 Cited by PubMed: 31692922DOI: 10.18632/oncotarget.27222 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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