6JP1

An X-ray structure of met sperm whale F43Y/T67R myoglobin with Tyr-heme double cross-links

Summary for 6JP1

• Entry DOI: 10.2210/pdb6jp1/pdb
• Descriptor: Myoglobin, PROTOPORPHYRIN IX CONTAINING FE (3 entities in total)
• Functional Keywords: sperm whale, myoglobin, oxygen transport
• Biological source: Physeter catodon (Sperm whale)
• Total number of polymer chains: 2
• Total formula weight: 35476.70

Authors

Lin, Y.W.,Yuan, H. (deposition date: 2019-03-25, release date: 2019-05-29, Last modification date: 2023-11-22)

Primary citation

Liu, C.,Yuan, H.,Liao, F.,Wei, C.W.,Du, K.J.,Gao, S.Q.,Tan, X.,Lin, Y.W.
Unique Tyr-heme double cross-links in F43Y/T67R myoglobin: an artificial enzyme with a peroxidase activity comparable to that of native peroxidases.
Chem.Commun.(Camb.), 55:6610-6613, 2019

PubMed Abstract: The X-ray crystal structure of F43Y/T67R myoglobin revealed unique Tyr-heme double cross-links between Tyr43 and the heme 4-vinyl group, which represents a novel post-translational modification of heme proteins. Moreover, with the feature of a distal His-Arg pair, the designed artificial enzyme exhibited a peroxidase activity comparable to that of native peroxidases, such as the most efficient horseradish peroxidase.

PubMed: 31119219
DOI: 10.1039/c9cc02714a

Experimental method

X-RAY DIFFRACTION (1.99 Å)