6JP1

An X-ray structure of met sperm whale F43Y/T67R myoglobin with Tyr-heme double cross-links

6JP1 の概要

• エントリーDOI: 10.2210/pdb6jp1/pdb
• 分子名称: Myoglobin, PROTOPORPHYRIN IX CONTAINING FE (3 entities in total)
• 機能のキーワード: sperm whale, myoglobin, oxygen transport
• 由来する生物種: Physeter catodon (Sperm whale)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 35476.70

構造登録者

Lin, Y.W.,Yuan, H. (登録日: 2019-03-25, 公開日: 2019-05-29, 最終更新日: 2023-11-22)

主引用文献

Liu, C.,Yuan, H.,Liao, F.,Wei, C.W.,Du, K.J.,Gao, S.Q.,Tan, X.,Lin, Y.W.
Unique Tyr-heme double cross-links in F43Y/T67R myoglobin: an artificial enzyme with a peroxidase activity comparable to that of native peroxidases.
Chem.Commun.(Camb.), 55:6610-6613, 2019

PubMed Abstract: The X-ray crystal structure of F43Y/T67R myoglobin revealed unique Tyr-heme double cross-links between Tyr43 and the heme 4-vinyl group, which represents a novel post-translational modification of heme proteins. Moreover, with the feature of a distal His-Arg pair, the designed artificial enzyme exhibited a peroxidase activity comparable to that of native peroxidases, such as the most efficient horseradish peroxidase.

PubMed: 31119219
DOI: 10.1039/c9cc02714a

実験手法

X-RAY DIFFRACTION (1.99 Å)