6JN3

Serine Beta-Lactamase KPC-2 in Complex with Dual MBL/SBL Inhibitor MS05

6JN3 の概要

• エントリーDOI: 10.2210/pdb6jn3/pdb
• 分子名称: Serine Beta-Lactamase KPC-2, [(1R)-1-[[(2S)-2-methyl-3-sulfanyl-propanoyl]amino]-2-phenyl-ethyl]boronic acid, DI(HYDROXYETHYL)ETHER, ... (5 entities in total)
• 機能のキーワード: beta-lactamase, serine-beta-lactamase kpc-2, kpc-2, carbapenemase, hydrolase
• 由来する生物種: Klebsiella pneumoniae
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 114444.03

構造登録者

Li, G.-B.,Liu, S. (登録日: 2019-03-13, 公開日: 2019-07-17, 最終更新日: 2023-11-22)

• 主引用文献: Wang, Y.L.,Liu, S.,Yu, Z.J.,Lei, Y.,Huang, M.Y.,Yan, Y.H.,Ma, Q.,Zheng, Y.,Deng, H.,Sun, Y.,Wu, C.,Yu, Y.,Chen, Q.,Wang, Z.,Wu, Y.,Li, G.B.; Structure-Based Development of (1-(3'-Mercaptopropanamido)methyl)boronic Acid Derived Broad-Spectrum, Dual-Action Inhibitors of Metallo- and Serine-beta-lactamases.; J.Med.Chem., 62:7160-7184, 2019; PubMed: 31269398; DOI: 10.1021/acs.jmedchem.9b00735

実験手法

X-RAY DIFFRACTION (2.216 Å)