6JMN

Crystal structure of Ostrinia furnacalis Chitinase h complexed with compound 2-8-s2

Summary for 6JMN

Entry DOI	10.2210/pdb6jmn/pdb
Descriptor	Chitinase, 6-azanyl-11-methyl-2-oxidanylidene-7-[[(2R)-oxolan-2-yl]methyl]-N-(pyridin-3-ylmethyl)-1,9-diaza-7-azoniatricyclo[8.4.0.0^{3,8}]tetradeca-3(8),4,6,9,11,13-hexaene-5-carboxamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
Functional Keywords	chitianse, complex, ostrinia furnacalis, inhibitor, hydrolase
Biological source	Ostrinia furnacalis (Asian corn borer)
Total number of polymer chains	1
Total formula weight	61957.57
Authors	Jiang, X.,Yang, Q. (deposition date: 2019-03-12, release date: 2020-05-06, Last modification date: 2023-11-22)
Primary citation	Jiang, X.,Kumar, A.,Motomura, Y.,Liu, T.,Zhou, Y.,Moro, K.,Zhang, K.Y.J.,Yang, Q. A Series of Compounds Bearing a Dipyrido-Pyrimidine Scaffold Acting as Novel Human and Insect Pest Chitinase Inhibitors. J.Med.Chem., 63:987-1001, 2020 Cited by PubMed: 31928006 DOI: 10.1021/acs.jmedchem.9b01154 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation