Summary for 6JMI
| Entry DOI | 10.2210/pdb6jmi/pdb |
| Descriptor | Uncharacterized HTH-type transcriptional regulator Rv0081, SULFATE ION (2 entities in total) |
| Functional Keywords | hypoxia, arsr/smtb, fhl regulator, regulatory hub, transcription |
| Biological source | Mycobacterium tuberculosis H37Rv |
| Total number of polymer chains | 4 |
| Total formula weight | 49749.22 |
| Authors | Kumar, A.,Phulera, S.,Mande, C.S. (deposition date: 2019-03-11, release date: 2019-04-10, Last modification date: 2024-03-27) |
| Primary citation | Kumar, A.,Phulera, S.,Rizvi, A.,Sonawane, P.J.,Panwar, H.S.,Banerjee, S.,Sahu, A.,Mande, S.C. Structural basis of hypoxic gene regulation by the Rv0081 transcription factor of Mycobacterium tuberculosis. Febs Lett., 593:982-995, 2019 Cited by PubMed Abstract: The transcription factor Rv0081 of Mycobacterium tuberculosis controls hypoxic gene expression and acts as a regulatory hub in the latent phase of tuberculosis (TB) infection. We report here the crystal structure of Rv0081 at 2.9 Å resolution revealing that it belongs to the well-known ArsR/SmtB family proteins. However, unlike other members in this family, Rv0081 has neither a metal-binding domain nor does it possess Cys residues, suggesting an alternate mechanism of gene regulation. Our structural and biochemical analyses suggest the molecular basis for the recognition of self-regulatory DNA sequences and a plausible mechanism of regulation of Rv0081 in the latent phase of TB infection. DATABASE: Structural data are available in the Protein Data Bank under the accession number - 6JMI. PubMed: 30941756DOI: 10.1002/1873-3468.13375 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.896 Å) |
Structure validation
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