6JMD

Crystal structure of human DHODH in complex with inhibitor 1223

Summary for 6JMD

Entry DOI	10.2210/pdb6jmd/pdb
Descriptor	Dihydroorotate dehydrogenase (quinone), mitochondrial, FLAVIN MONONUCLEOTIDE, OROTIC ACID, ... (8 entities in total)
Functional Keywords	dhodh, inhibitor, complex, oxidoreductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	41294.76
Authors	Yu, Y.,Chen, Q. (deposition date: 2019-03-08, release date: 2020-03-18, Last modification date: 2024-03-27)
Primary citation	Zuo, Z.,Liu, X.,Qian, X.,Zeng, T.,Sang, N.,Liu, H.,Zhou, Y.,Tao, L.,Zhou, X.,Su, N.,Yu, Y.,Chen, Q.,Luo, Y.,Zhao, Y. Bifunctional Naphtho[2,3- d ][1,2,3]triazole-4,9-dione Compounds Exhibit Antitumor Effects In Vitro and In Vivo by Inhibiting Dihydroorotate Dehydrogenase and Inducing Reactive Oxygen Species Production. J.Med.Chem., 63:7633-7652, 2020 Cited by PubMed: 32496056 DOI: 10.1021/acs.jmedchem.0c00512 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.781 Å)

Structure validation