6JKA

Crystal structure of metallo-beta-lactamse, IMP-1, in complex with a thiazole-bearing inhibitor

Summary for 6JKA

• Entry DOI: 10.2210/pdb6jka/pdb
• Descriptor: Metallo-beta-lactamase type 2, ZINC ION, 6-[2-(phenoxymethyl)-1,3-thiazol-4-yl]-3,4-dihydro-1H-quinolin-2-one, ... (5 entities in total)
• Functional Keywords: hydrolase
• Biological source: Serratia marcescens
• Total number of polymer chains: 4
• Total formula weight: 101612.60

Authors

Kamo, T.,Kuroda, K.,Kondo, S.,Hayashi, U.,Fudo, S.,Nukaga, M.,Hoshino, T. (deposition date: 2019-02-28, release date: 2020-03-25, Last modification date: 2023-11-22)

• Primary citation: Kamo, T.,Kuroda, K.,Kondo, S.,Hayashi, U.,Fudo, S.,Yoneda, T.,Takaya, A.,Nukaga, M.,Hoshino, T.; Identification of the Inhibitory Compounds for Metallo-beta-lactamases and Structural Analysis of the Binding Modes.; Chem Pharm Bull (Tokyo), 69:1179-1183, 2021; PubMed: 34853284; DOI: 10.1248/cpb.c21-00611

Experimental method

X-RAY DIFFRACTION (2.006 Å)