6JJX

Crystal Structure of KIBRA and Angiomotin complex

6JJX の概要

• エントリーDOI: 10.2210/pdb6jjx/pdb
• 分子名称: Protein KIBRA, Peptide from Angiomotin (3 entities in total)
• 機能のキーワード: ww tandem, py tandem, kibra, angiomotin, amot, signaling protein
• 由来する生物種: Mus musculus (Mouse); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 37649.35

構造登録者

Lin, Z.,Yang, Z.,Ji, Z.,Zhang, M. (登録日: 2019-02-27, 公開日: 2019-09-25, 最終更新日: 2024-10-16)

主引用文献

Lin, Z.,Yang, Z.,Xie, R.,Ji, Z.,Guan, K.,Zhang, M.
Decoding WW domain tandem-mediated target recognitions in tissue growth and cell polarity.
Elife, 8:-, 2019

PubMed Abstract: WW domain tandem-containing proteins such as KIBRA, YAP, and MAGI play critical roles in cell growth and polarity via binding to and positioning target proteins in specific subcellular regions. An immense disparity exists between promiscuity of WW domain-mediated target bindings and specific roles of WW domain proteins in cell growth regulation. Here, we discovered that WW domain tandems of KIBRA and MAGI, but not YAP, bind to specific target proteins with extremely high affinity and exquisite sequence specificity. Via systematic structural biology and biochemistry approaches, we decoded the target binding rules of WW domain tandems from cell growth regulatory proteins and uncovered a list of previously unknown WW tandem binding proteins including β-Dystroglycan, JCAD, and PTPN21. The WW tandem-mediated target recognition mechanisms elucidated here can guide functional studies of WW domain proteins in cell growth and polarity as well as in other cellular processes including neuronal synaptic signaling.

PubMed: 31486770
DOI: 10.7554/eLife.49439

実験手法

X-RAY DIFFRACTION (2 Å)