6JDJ

Crystal structure of AcrIIC2 dimer in complex with partial Nme1Cas9

Summary for 6JDJ

• Entry DOI: 10.2210/pdb6jdj/pdb
• Descriptor: AcrIIC2, CRISPR-associated endonuclease Cas9 (3 entities in total)
• Functional Keywords: crispr-cas9, nme1cas9, nmecas9, anti-crispr, acriic2, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Neisseria meningitidis 8013; More
• Total number of polymer chains: 3
• Total formula weight: 37184.87

Authors

Cheng, Z.,Huang, X.,Sun, W.,Wang, Y. (deposition date: 2019-02-01, release date: 2019-05-15, Last modification date: 2023-11-22)

• Primary citation: Thavalingam, A.,Cheng, Z.,Garcia, B.,Huang, X.,Shah, M.,Sun, W.,Wang, M.,Harrington, L.,Hwang, S.,Hidalgo-Reyes, Y.,Sontheimer, E.J.,Doudna, J.,Davidson, A.R.,Moraes, T.F.,Wang, Y.,Maxwell, K.L.; Inhibition of CRISPR-Cas9 ribonucleoprotein complex assembly by anti-CRISPR AcrIIC2.; Nat Commun, 10:2806-2806, 2019; PubMed: 31243272; DOI: 10.1038/s41467-019-10577-3

Experimental method

X-RAY DIFFRACTION (2.6 Å)