6J99

Cryo-EM structure of human DOT1L in complex with an H2B-monoubiquitinated nucleosome

Summary for 6J99

• Entry DOI: 10.2210/pdb6j99/pdb
• EMDB information: 9783
• Descriptor: Histone H3, Histone H4, Histone H2A, ... (9 entities in total)
• Functional Keywords: epigenetics, nucleosome, dot1l, histone modification, transcription
• Biological source: Xenopus laevis (African clawed frog); More
• Total number of polymer chains: 12
• Total formula weight: 256400.10

Authors

Yao, T.,Huang, J. (deposition date: 2019-01-22, release date: 2019-02-27, Last modification date: 2019-04-10)

• Primary citation: Yao, T.,Jing, W.,Hu, Z.,Tan, M.,Cao, M.,Wang, Q.,Li, Y.,Yuan, G.,Lei, M.,Huang, J.; Structural basis of the crosstalk between histone H2B monoubiquitination and H3 lysine 79 methylation on nucleosome.; Cell Res., 29:330-333, 2019; PubMed: 30770869; DOI: 10.1038/s41422-019-0146-7

Experimental method

ELECTRON MICROSCOPY (4.1 Å)