6J6M

Co-crystal structure of BTK kinase domain with Zanubrutinib

6J6M の概要

• エントリーDOI: 10.2210/pdb6j6m/pdb
• 分子名称: Tyrosine-protein kinase BTK, (7S)-2-(4-phenoxyphenyl)-7-(1-propanoylpiperidin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide, IMIDAZOLE, ... (4 entities in total)
• 機能のキーワード: kinase, inhibitor, complex, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 31894.64

構造登録者

Zhou, X.,Hong, Y. (登録日: 2019-01-15, 公開日: 2019-10-23, 最終更新日: 2023-11-22)

• 主引用文献: Guo, Y.,Liu, Y.,Hu, N.,Yu, D.,Zhou, C.,Shi, G.,Zhang, B.,Wei, M.,Liu, J.,Luo, L.,Tang, Z.,Song, H.,Guo, Y.,Liu, X.,Su, D.,Zhang, S.,Song, X.,Zhou, X.,Hong, Y.,Chen, S.,Cheng, Z.,Young, S.,Wei, Q.,Wang, H.,Wang, Q.,Lv, L.,Wang, F.,Xu, H.,Sun, H.,Xing, H.,Li, N.,Zhang, W.,Wang, Z.,Liu, G.,Sun, Z.,Zhou, D.,Li, W.,Liu, L.,Wang, L.,Wang, Z.; Discovery of Zanubrutinib (BGB-3111), a Novel, Potent, and Selective Covalent Inhibitor of Bruton's Tyrosine Kinase.; J.Med.Chem., 62:7923-7940, 2019; PubMed: 31381333; DOI: 10.1021/acs.jmedchem.9b00687

実験手法

X-RAY DIFFRACTION (1.25 Å)