6J3P

Crystal structure of the human GCN5 bromodomain in complex with compound (R,R)-36n

6J3P の概要

• エントリーDOI: 10.2210/pdb6j3p/pdb
• 分子名称: Histone acetyltransferase KAT2A, 2-{[(3R,5R)-5-(2,3-dihydro-1,4-benzodioxin-6-yl)-1-methylpiperidin-3-yl]amino}-3-methyl-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one (3 entities in total)
• 機能のキーワード: crystal structure of the human gcn5 bromodomain in complex with compound (r, r)-36n, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 32793.55

構造登録者

Huang, L.Y.,Li, H.,Niu, L.,Wu, C.Y.,Yu, Y.M.,Li, L.L.,Yang, S.Y. (登録日: 2019-01-05, 公開日: 2019-05-01, 最終更新日: 2023-11-22)

• 主引用文献: Huang, L.,Li, H.,Li, L.,Niu, L.,Seupel, R.,Wu, C.,Cheng, W.,Chen, C.,Ding, B.,Brennan, P.E.,Yang, S.; Discovery of Pyrrolo[3,2- d]pyrimidin-4-one Derivatives as a New Class of Potent and Cell-Active Inhibitors of P300/CBP-Associated Factor Bromodomain.; J.Med.Chem., 62:4526-4542, 2019; PubMed: 30998845; DOI: 10.1021/acs.jmedchem.9b00096

実験手法

X-RAY DIFFRACTION (1.598 Å)