6J3O
Crystal structure of the human PCAF bromodomain in complex with compound 12
Summary for 6J3O
| Entry DOI | 10.2210/pdb6j3o/pdb |
| Descriptor | Histone acetyltransferase KAT2B, 3-methyl-2-[[(3~{R})-1-methylpiperidin-3-yl]amino]-5~{H}-pyrrolo[3,2-d]pyrimidin-4-one (3 entities in total) |
| Functional Keywords | crystal structure of the human pcaf bromodomain in complex with compound 12, transferase |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 2 |
| Total formula weight | 33810.74 |
| Authors | Huang, L.Y.,Li, H.,Li, L.L.,Niu, L.,Seupel, R.,Wu, C.Y.,Li, G.B.,Yu, Y.M.,Brennan, P.E.,Yang, S.Y. (deposition date: 2019-01-05, release date: 2019-05-01, Last modification date: 2023-11-22) |
| Primary citation | Huang, L.,Li, H.,Li, L.,Niu, L.,Seupel, R.,Wu, C.,Cheng, W.,Chen, C.,Ding, B.,Brennan, P.E.,Yang, S. Discovery of Pyrrolo[3,2- d]pyrimidin-4-one Derivatives as a New Class of Potent and Cell-Active Inhibitors of P300/CBP-Associated Factor Bromodomain. J.Med.Chem., 62:4526-4542, 2019 Cited by PubMed: 30998845DOI: 10.1021/acs.jmedchem.9b00096 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.11 Å) |
Structure validation
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