6J3B

Crystal structure of human DHODH in complex with inhibitor 1289

6J3B の概要

• エントリーDOI: 10.2210/pdb6j3b/pdb
• 分子名称: Dihydroorotate dehydrogenase (quinone), mitochondrial, SODIUM ION, SULFATE ION, ... (11 entities in total)
• 機能のキーワード: dhodh, inhibitor, complex, oxidoreductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 42221.84

構造登録者

Yu, Y.,Chen, Q. (登録日: 2019-01-04, 公開日: 2019-08-21, 最終更新日: 2024-03-27)

• 主引用文献: Zeng, T.,Zuo, Z.,Luo, Y.,Zhao, Y.,Yu, Y.,Chen, Q.; A novel series of human dihydroorotate dehydrogenase inhibitors discovered by in vitro screening: inhibition activity and crystallographic binding mode.; Febs Open Bio, 9:1348-1354, 2019; PubMed: 31087527; DOI: 10.1002/2211-5463.12658

実験手法

X-RAY DIFFRACTION (1.6 Å)