6J26

Crystal structure of the branched-chain polyamine synthase from Thermococcus kodakarensis (Tk-BpsA) in complex with N4-bis(aminopropyl)spermidine and 5'-methylthioadenosine

Summary for 6J26

• Entry DOI: 10.2210/pdb6j26/pdb
• Descriptor: N(4)-bis(aminopropyl)spermidine synthase, 5'-DEOXY-5'-METHYLTHIOADENOSINE, N~1~,N~1~,N~1~-tris(3-azaniumylpropyl)butane-1,4-diaminium, ... (5 entities in total)
• Functional Keywords: n(4)-bis(aminopropyl)spermidine synthase, polyamine biosynthesis, spermidine, branched polyamines, transferase
• Biological source: Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)
• Total number of polymer chains: 2
• Total formula weight: 86071.34

Authors

Mizohata, E.,Toyoda, M.,Fujita, J.,Inoue, T. (deposition date: 2018-12-31, release date: 2019-06-26, Last modification date: 2023-11-22)

• Primary citation: Hidese, R.,Toyoda, M.,Yoshino, K.I.,Fukuda, W.,Wihardja, G.A.,Kimura, S.,Fujita, J.,Niitsu, M.,Oshima, T.,Imanaka, T.,Mizohata, E.,Fujiwara, S.; The C-terminal flexible region of branched-chain polyamine synthase facilitates substrate specificity and catalysis.; Febs J., 286:3926-3940, 2019; PubMed: 31162806; DOI: 10.1111/febs.14949

Experimental method

X-RAY DIFFRACTION (2 Å)