6J0Z

Crystal structure of AlpK

Summary for 6J0Z

Entry DOI	10.2210/pdb6j0z/pdb
Descriptor	Putative angucycline-like polyketide oxygenase, FLAVIN-ADENINE DINUCLEOTIDE (2 entities in total)
Functional Keywords	putative oxygenase, fad-binding, oxidoreductase
Biological source	Streptomyces ambofaciens
Total number of polymer chains	1
Total formula weight	53105.74
Authors	Wang, W.,Liu, Y.,Liang, H. (deposition date: 2018-12-27, release date: 2019-03-06, Last modification date: 2023-11-22)
Primary citation	Wang, W.,Li, J.,Li, H.,Fan, K.,Liu, Y. Crystal structure of AlpK: An essential monooxygenase involved in the biosynthesis of kinamycin Biochem. Biophys. Res. Commun., 510:601-605, 2019 Cited by PubMed Abstract: AlpK is an essential monooxygenase involved in the biosynthesis of kinamycin. It catalyzes the C5-hyfroxylattion of the crucial benzo[b]-fluorence intermediate in kinamycin synthesis. However, the structure and mechanism of AlpK is unclear. Here, we report the first structure of AlpK in complex with FAD. Our structure sheds light on the catalytic mechanism of AlpK. PubMed: 30739782 DOI: 10.1016/j.bbrc.2019.01.077 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.889 Å)

Structure validation