6IZP

Solution structure of the complex of naphthyridine carbamate dimer and an RNA with UGGAA-UGGAA pentad

6IZP の概要

• エントリーDOI: 10.2210/pdb6izp/pdb
• 分子名称: RNA (29-MER), 3-[3-[(7-methyl-1,8-naphthyridin-2-yl)carbamoyloxy]propylamino]propyl ~{N}-(7-methyl-1,8-naphthyridin-2-yl)carbamate (2 entities in total)
• 機能のキーワード: sca31, uggaa repeat, small molecule, drug, rna
• 由来する生物種: Homo sapiens
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 10333.66

構造登録者

Nagano, K.,Shibata, T.,Nakatani, K.,Kawai, G. (登録日: 2018-12-20, 公開日: 2019-12-25, 最終更新日: 2024-05-15)

• 主引用文献: Shibata, T.,Nagano, K.,Ueyama, M.,Ninomiya, K.,Hirose, T.,Nagai, Y.,Ishikawa, K.,Kawai, G.,Nakatani, K.; Small molecule targeting r(UGGAA)n disrupts RNA foci and alleviates disease phenotype in Drosophila model; Nat Commun, 12:-, 2021; DOI: 10.1038/s41467-020-20487-4

実験手法

SOLUTION NMR