6IYW

Crystal sturucture of L,D-transpeptidase LdtMt2 from Mycobacterium tuberculosis in complex with Imipenem adduct

Summary for 6IYW

Entry DOI	10.2210/pdb6iyw/pdb
Related	3VYO 3VYP
Descriptor	L,D-transpeptidase 2, (5R)-5-[(1S,2R)-1-formyl-2-hydroxypropyl]-3-[(2-{[(E)-iminomethyl]amino}ethyl)sulfanyl]-4,5-dihydro-1H-pyrrole-2-carbox ylic acid, GLYCEROL, ... (4 entities in total)
Functional Keywords	ld-transpeptidase, peptidoglycan synthesis enzyme, beta-lactam binding, transferase
Biological source	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Total number of polymer chains	6
Total formula weight	181334.59
Authors	Li, D.F.,Zhao, F.,Wang, D.C. (deposition date: 2018-12-17, release date: 2019-02-27, Last modification date: 2023-11-22)
Primary citation	Zhao, F.,Hou, Y.J.,Zhang, Y.,Wang, D.C.,Li, D.F. The 1-beta-methyl group confers a lower affinity of l,d-transpeptidase LdtMt2 for ertapenem than for imipenem. Biochem. Biophys. Res. Commun., 510:254-260, 2019 Cited by PubMed: 30686533 DOI: 10.1016/j.bbrc.2019.01.082 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation