6IYV
Crystal sturucture of L,D-transpeptidase LdtMt2 from Mycobacterium tuberculosis in complex with ertapenem adduct
Summary for 6IYV
Entry DOI | 10.2210/pdb6iyv/pdb |
Related | 3VYO 3VYP |
Descriptor | L,D-transpeptidase 2, (2S,3R,4S)-4-({(3S,5S)-5-[(3-carboxyphenyl)carbamoyl]pyrrolidin-3-yl}sulfanyl)-2-[(1S,2R)-1-formyl-2-hydroxypropyl]-3-methyl-3,4-dihydro-2H-pyrrole-5-carboxylic acid, GLYCEROL, ... (7 entities in total) |
Functional Keywords | ld-transpeptidase, peptidoglycan synthesis enzyme, beta-lactam binding, transferase |
Biological source | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
Total number of polymer chains | 2 |
Total formula weight | 61411.83 |
Authors | Zhao, F.,Li, D.F.,Wang, D.C. (deposition date: 2018-12-17, release date: 2019-02-27, Last modification date: 2023-11-22) |
Primary citation | Zhao, F.,Hou, Y.J.,Zhang, Y.,Wang, D.C.,Li, D.F. The 1-beta-methyl group confers a lower affinity of l,d-transpeptidase LdtMt2for ertapenem than for imipenem. Biochem. Biophys. Res. Commun., 510:254-260, 2019 Cited by PubMed: 30686533DOI: 10.1016/j.bbrc.2019.01.082 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.5 Å) |
Structure validation
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