6IW2

Crystal structure of 5A ScFv in complex with YFV-17D sE in prefusion state

6IW2 の概要

• エントリーDOI: 10.2210/pdb6iw2/pdb
• 分子名称: Envelope protein E, Heavy chain of monoclonal antibody 5A, Light chain of monoclonal antibody 5A (3 entities in total)
• 機能のキーワード: yellow fever virus, neutralizing monoclonal antibody, envelope protein, flavivirus, viral protein, viral protein-immune system complex, viral protein/immune system
• 由来する生物種: Yellow fever virus (strain 17D vaccine) (YFV); 詳細
• タンパク質・核酸の鎖数: 18
• 化学式量合計: 410867.59

構造登録者

Lu, X.S.,Xiao, H.X.,Li, S.H.,Pang, X.F. (登録日: 2018-12-04, 公開日: 2019-02-13)

• 主引用文献: Lu, X.,Xiao, H.,Li, S.,Pang, X.,Song, J.,Liu, S.,Cheng, H.,Li, Y.,Wang, X.,Huang, C.,Guo, T.,Ter Meulen, J.,Daffis, S.,Yan, J.,Dai, L.,Rao, Z.,Klenk, H.D.,Qi, J.,Shi, Y.,Gao, G.F.; Double Lock of a Human Neutralizing and Protective Monoclonal Antibody Targeting the Yellow Fever Virus Envelope.; Cell Rep, 26:438-446.e5, 2019; PubMed: 30625326; DOI: 10.1016/j.celrep.2018.12.065

実験手法

X-RAY DIFFRACTION (2.9 Å)