6ITX

Structure of the C-terminal head domain of the avian adenovirus EDSV fiber

6ITX の概要

• エントリーDOI: 10.2210/pdb6itx/pdb
• 分子名称: Fiber protein, GLUTAMINE, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: avian adenovirus, fiber protein, cell adhesion
• 由来する生物種: Duck adenovirus 1
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 193816.69

構造登録者

Wei, Q.,Song, Y. (登録日: 2018-11-26, 公開日: 2019-10-09, 最終更新日: 2024-03-27)

主引用文献

Song, Y.,Wei, Q.,Liu, Y.,Feng, H.,Chen, Y.,Wang, Y.,Bai, Y.,Xing, G.,Deng, R.,Zhang, G.
Unravelling the receptor binding property of egg drop syndrome virus (EDSV) from the crystal structure of EDSV fiber head.
Int.J.Biol.Macromol., 139:587-595, 2019

PubMed Abstract: Egg drop syndrome virus (EDSV) is an avian adenovirus that causes markedly decrease in egg production, and in the quality of the eggs when it infects chickens. Until now, EDSV virus-cell interactions are poorly understood, and the cellular receptor is still unknown. In the present study, we determined the atomic structure of the fiber head of EDSV (residues 377-644) at 2.74 Å resolution. Structure comparison with the (chick embryo lethal orphan) CELO long fiber head and human adenovirus fiber heads reveals that the avian adenovirus may interact with the same attachment factor in a unique fashion. Based on the previous studies of CELO virus, we assumed that the chicken coxsackievirus and adenovirus receptor (CAR) may be the attachment factor. We then demonstrate that the chicken CAR serves as a cellular attachment factor for EDSV based on three lines of evidences. Taken together, the results presented here are helpful for further exploring the pathogenesis related to the interaction between EDSV and host cells, and may be used for vaccine development and intervention strategies against EDSV infection.

PubMed: 31381914
DOI: 10.1016/j.ijbiomac.2019.08.005

実験手法

X-RAY DIFFRACTION (2.75 Å)