6IQC
Wild-type Programmed Cell Death 5 protein from Sulfolobus solfataricus
Summary for 6IQC
| Entry DOI | 10.2210/pdb6iqc/pdb |
| Descriptor | DNA-binding protein SSO0352, TETRAETHYLENE GLYCOL, SODIUM ION, ... (4 entities in total) |
| Functional Keywords | dna binding protein, sulfolobus |
| Biological source | Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) |
| Total number of polymer chains | 1 |
| Total formula weight | 14295.26 |
| Authors | Chen, C.Y.,Lin, K.F.,Hsu, C.Y.,Tsai, M.J. (deposition date: 2018-11-06, release date: 2019-02-20, Last modification date: 2023-11-22) |
| Primary citation | Lin, K.F.,Hsu, J.Y.,Hsieh, D.L.,Tsai, M.J.,Yeh, C.H.,Chen, C.Y. Crystal structure of the programmed cell death 5 protein from Sulfolobus solfataricus. Acta Crystallogr F Struct Biol Commun, 75:73-79, 2019 Cited by PubMed Abstract: Programmed cell death 5 (PDCD5) is a vital signaling protein in the apoptosis pathway in eukaryotes. It is known that there are two dissociated N-terminal regions and a triple-helix core in eukaryotic PDCD5. Structural and functional studies of PDCD5 from hyperthermophilic archaea have been limited to date. Here, the PDCD5 homolog Sso0352 (SsoPDCD5) was identified in Sulfolobus solfataricus, the SsoPDCD5 protein was expressed and crystallized, and the phase was identified by single-wavelength anomalous diffraction. The native SsoPDCD5 crystal belonged to space group C2 and diffracted to 1.49 Å resolution. This is the first crystal structure of a PDCD5 homolog to be solved. SsoPDCD5 shares a similar triple-helix bundle with eukaryotic PDCD5 but has a long α-helix in the N-terminus. A structural search and biochemical data suggest that SsoPDCD5 may function as a DNA-binding protein. PubMed: 30713157DOI: 10.1107/S2053230X18017673 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.49 Å) |
Structure validation
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