6IQ4

Nucleosome core particle cross-linked with a hetero-binuclear molecule possessing RAPTA and gold(I) 4-(diphenylphosphino)benzoic acid groups.

6IQ4 の概要

• エントリーDOI: 10.2210/pdb6iq4/pdb
• 分子名称: Histone H3.1, MAGNESIUM ION, [Ru(eta(6)-p-cymene)Cl-2(pta), ... (12 entities in total)
• 機能のキーワード: nucleosome, anticancer, organometallic, cross-link, gold, ruthenium, dna binding protein-dna complex, dna binding protein/dna
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 10
• 化学式量合計: 177347.31

構造登録者

DeFalco, L.,Batchelor, L.K.,Adhireksan, Z.,Dyson, P.J.,Davey, C.A. (登録日: 2018-11-06, 公開日: 2019-10-30, 最終更新日: 2024-03-27)

• 主引用文献: Batchelor, L.K.,De Falco, L.,von Erlach, T.,Sharma, D.,Adhireksan, Z.,Roethlisberger, U.,Davey, C.A.,Dyson, P.J.; Crosslinking Allosteric Sites on the Nucleosome.; Angew.Chem.Int.Ed.Engl., 58:15660-15664, 2019; PubMed: 31478581; DOI: 10.1002/anie.201906423

実験手法

X-RAY DIFFRACTION (2.25 Å)