6INK
Crystal structure of PDE4D complexed with a novel inhibitor
Summary for 6INK
Entry DOI | 10.2210/pdb6ink/pdb |
Descriptor | cAMP-specific 3',5'-cyclic phosphodiesterase 4D, ZINC ION, MAGNESIUM ION, ... (6 entities in total) |
Functional Keywords | pde4d, inhibitor, complex, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 81349.29 |
Authors | Zhang, X.L.,Su, H.X.,Xu, Y.C. (deposition date: 2018-10-25, release date: 2019-10-23, Last modification date: 2024-03-27) |
Primary citation | Zhang, X.,Dong, G.,Li, H.,Chen, W.,Li, J.,Feng, C.,Gu, Z.,Zhu, F.,Zhang, R.,Li, M.,Tang, W.,Liu, H.,Xu, Y. Structure-Aided Identification and Optimization of Tetrahydro-isoquinolines as Novel PDE4 Inhibitors Leading to Discovery of an Effective Antipsoriasis Agent. J.Med.Chem., 62:5579-5593, 2019 Cited by PubMed: 31099559DOI: 10.1021/acs.jmedchem.9b00518 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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