6IMO

Crystal structure of PDE4D complexed with a novel inhibitor

Summary for 6IMO

Entry DOI	10.2210/pdb6imo/pdb
Descriptor	cAMP-specific 3',5'-cyclic phosphodiesterase 4D, ZINC ION, MAGNESIUM ION, ... (6 entities in total)
Functional Keywords	pde4d, inhibitor, complex, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	81842.08
Authors	Zhang, X.L.,Su, H.X.,Xu, Y.C. (deposition date: 2018-10-23, release date: 2019-10-23, Last modification date: 2023-11-22)
Primary citation	Zhang, X.,Dong, G.,Li, H.,Chen, W.,Li, J.,Feng, C.,Gu, Z.,Zhu, F.,Zhang, R.,Li, M.,Tang, W.,Liu, H.,Xu, Y. Structure-Aided Identification and Optimization of Tetrahydro-isoquinolines as Novel PDE4 Inhibitors Leading to Discovery of an Effective Antipsoriasis Agent. J.Med.Chem., 62:5579-5593, 2019 Cited by PubMed: 31099559 DOI: 10.1021/acs.jmedchem.9b00518 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.55 Å)

Structure validation