6IM6

Crystal structure of PDE4D complexed with a novel inhibitor

6IM6 の概要

• エントリーDOI: 10.2210/pdb6im6/pdb
• 分子名称: cAMP-specific 3',5'-cyclic phosphodiesterase 4D, ZINC ION, MAGNESIUM ION, ... (6 entities in total)
• 機能のキーワード: pde4d, inhibitor, complex, apremilast, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 81698.19

構造登録者

Zhang, X.L.,Su, H.X.,Xu, Y.C. (登録日: 2018-10-22, 公開日: 2019-10-23, 最終更新日: 2024-03-27)

• 主引用文献: Zhang, X.,Dong, G.,Li, H.,Chen, W.,Li, J.,Feng, C.,Gu, Z.,Zhu, F.,Zhang, R.,Li, M.,Tang, W.,Liu, H.,Xu, Y.; Structure-Aided Identification and Optimization of Tetrahydro-isoquinolines as Novel PDE4 Inhibitors Leading to Discovery of an Effective Antipsoriasis Agent.; J.Med.Chem., 62:5579-5593, 2019; PubMed: 31099559; DOI: 10.1021/acs.jmedchem.9b00518

実験手法

X-RAY DIFFRACTION (1.702 Å)