6ILQ

Crystal structure of PPARgamma with compound BR101549

6ILQ の概要

• エントリーDOI: 10.2210/pdb6ilq/pdb
• 分子名称: Peroxisome proliferator-activated receptor gamma, Nuclear receptor coactivator 1, ethyl [2-butyl-6-oxo-1-{[2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]methyl}-4-(propan-2-yl)-1,6-dihydropyrimidin-5-yl]acetate, ... (4 entities in total)
• 機能のキーワード: peroxisome proliferator-activated receptor-g(ppar-g), transcription factor, ligand-binding domain, steroid receptor coactivator-1, nuclear protein
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 34430.91

構造登録者

Hong, E.,Jang, T.H.,Chin, J.,Kim, K.H.,Jung, W.,Kim, S.H. (登録日: 2018-10-19, 公開日: 2019-09-11, 最終更新日: 2023-11-22)

• 主引用文献: Choung, W.,Jung, H.J.,Yang, D.,Nam, E.H.,Choi, H.,Lee, B.R.,Park, M.,Jang, S.M.,Lim, J.S.,Kim, W.S.,Kim, K.H.,Chin, J.,Jung, K.,Lee, G.,Hong, E.,Jang, T.H.,Myung, J.,Kim, S.H.; Identification of BR101549 as a lead candidate of non-TZD PPAR gamma agonist for the treatment of type 2 diabetes: Proof-of-concept evaluation and SAR.; Bioorg.Med.Chem.Lett., 29:631-637, 2019; PubMed: 30594432; DOI: 10.1016/j.bmcl.2018.12.043

実験手法

X-RAY DIFFRACTION (2.408 Å)