6IIY

Crystal structure of deacetylase triple mutant (Orf2*T) that involving in teicoplanin biosynthetic pathway

6IIY の概要

• エントリーDOI: 10.2210/pdb6iiy/pdb
• 分子名称: deacetylase, IMIDAZOLE, COBALT (II) ION, ... (4 entities in total)
• 機能のキーワード: antibiotics, oxidoreductase
• 由来する生物種: Actinoplanes teichomyceticus
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 32378.78

構造登録者

Li, T.L.,Huang, C.M. (登録日: 2018-10-08, 公開日: 2019-10-09, 最終更新日: 2023-11-22)

• 主引用文献: Huang, C.M.,Lyu, S.Y.,Lin, K.H.,Chen, C.L.,Chen, M.H.,Shih, H.W.,Hsu, N.S.,Lo, I.W.,Wang, Y.L.,Li, Y.S.,Wu, C.J.,Li, T.L.; Teicoplanin Reprogrammed with the N-Acyl-Glucosamine Pharmacophore at the Penultimate Residue of Aglycone Acquires Broad-Spectrum Antimicrobial Activities Effectively Killing Gram-Positive and -Negative Pathogens.; Acs Infect Dis., 5:430-442, 2019; PubMed: 30599088; DOI: 10.1021/acsinfecdis.8b00317

実験手法

X-RAY DIFFRACTION (1.29 Å)